Generic Name: Etoricoxib 60mg
Manufacturer/Distributor: Popular Pharmaceuticals Ltd.
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Indications of Cox-E 60
Cox-E is a medication that relieves pain. It is used to treat mild joint pain and swelling brought on by various gout and arthritis types. Additionally, it is employed in the short-term management of moderate post-dental surgery pain in patients 16 years of age and older.
Pharmacology
Etoricoxib is a strong, orally active cyclooxygenase-2 (COX-2) specific inhibitor that is effective within and significantly above the clinical dose range. There are two isoforms of cyclooxygenase: cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) (COX-2). Normal physiologic processes mediated by prostaglandins, such as platelet aggregation and gastric cytoprotection, are controlled by COX-1.
Dosage & Administration
Adults and Adolescents over 16 years:
Certain patients might need more postoperative analgesia. The shortest duration and lowest effective daily dose should be used because the cardiovascular risks of etoricoxib may increase with the dose and duration of exposure. Periodic reevaluations of the patient's need for symptomatic relief and response to treatment are recommended, particularly in cases of osteoarthritis.
Interaction of Cox-E 60
Using medication: Oral anticoagulants: The administration of Etorcoxib was associated with an increase in prothrombin time in subjects stabilized on continuous warfarin therapy. Angiotensin II antagonists, expert inhibitors, and diuretics: NSAIDs may lessen how diuretics and other antihypertensive medications work. Acetylsalicylic Corrosive: At dosages used for cardiovascular prophylaxis, etoricoxib can be taken concurrently with acetylsalicylic corrosive (low-dose acetylsalicylic acid). Tacrolimus and ciclosporin: Although this interaction has not been studied with etoricoxib, cyclosporin, or tacrolimus coadministration with any NSAID may increase the nephrotoxic effects of ciclosporin or tacrolimus. Lithium: NSAIDs reduce the renal excretion of lithium, which raises plasma levels of the metal. Take without regard to suppers with food and others.
Contraindications
Discomfort with the active ingredient or with any of the excipients. Dynamic gastrointestinal bleeding or active peptic ulceration Patients taking acetylsalicylic acid or NSAIDs including COX-2 (cyclooxygenase-2) inhibitors who have developed bronchospasm, severe rhinitis, nasal polyps, angioneurotic edema, urticaria, or allergic-type reactions. lactation and pregnancy. severe liver damage (Child-Pugh score of 10 or serum egg whites less than 25 g/l). Relative renal creatinine clearance of 30 ml/min or less. Children and young people under the age of 16 years. intestinal inflammation. disappointment with congestive heart (NYHA ll-IV). Patients with hypertension whose blood pressure is consistently raised over 140/90 mmHg and has not been sufficiently controlled established ischaemic heart infection, cerebrovascular disease, or a condition affecting peripheral blood vessels.
Side Effects of Cox-E 60
Palpitations, fatigue, side effects similar to the flu, and ecchymosis are possible side effects. Less frequently occurring side effects include dry mouth, taste disturbance, mouth ulcers, cravings, weight changes, atrial fibrillation, transient ischaemic attack, chest pain, flushing, hacking, dyspnea, epistaxis, unease, impaired mental sharpness, paraesthesia, electrolyte disturbance, myalgia, and arthralgia.
Pregnancy & Lactation
The utilize of Etoricoxib, as with any sedate substance known to restrain COX-2, isn't prescribed in ladies endeavoring to conceive. It isn't known whether Etoricoxib is excreted in human drain. Etoricoxib is excreted within the drain of lactating rats. Ladies who utilize Etoricoxib must not breastfeed.
Precautions & Warnings
Storage Conditions
Protect from light and moisture by storing below 30°C. Keep the medicine out of children's reach.
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